Pseudo-Tetrahedral Copper(I) Symmetrical Formamidine Dithiocarbamate-Phosphine Complexes: Antibacterial, Antioxidant and Pharmacokinetics Studies

Three copper(I) dithiocarbamate–phosphine complexes of the general formula Cu(PPh3)2L were synthesized by metathesis reactions potassium salt dithiocarbamate ligand L and precursor complex Cu(PPh3)2NO3 in an equimolar ratio. represents N,N?-bis(2,6-dimethylphenyl)formamidine L1 1, N,N?-bis(2,6-disopropylphenyl) formamidine L2 2, N,N?-dimesitylformamidine L3 3. The single-crystal X-ray structure revealed coordination copper atom to two sulfur atoms dithiocarbamates, as well phosphorus PPh3 units, which resulted distorted tetrahedral geometries. calculated ?4 (tau factor) values for 2 3 0.82, 0.81 0.85, respectively, confirming pseudo-tetrahedral geometry proposed. Complexes 1–3 showed remarkable luminescent properties CH2Cl2 at room temperature. All three moderate-to-low antibacterial potential against Gram-negative bacteria, while none active Gram-positive bacteria. DPPH assay studies that had lowest IC50 (4.99 × 10?3 mM),and higher free radical scavenging ability than 1 pharmacological estimations all minimal violation Lipinski’s rule.